Examples of common medications that have a grapefruit juice interaction include felodipine (Plendil) and atorvastatin (Lipitor). If you drink grapefruit juice, always have your pharmacist run a drug interaction check with your medications to rule out an interaction before you combine them. Grapefruit juice and the actual grapefruit can be part of a healthy diet. Grapefruit has vitamin C and potassium—nutrients your body needs to work properly. But it isn’t good for you when it. Grapefruit products are believed to interfere with an enzyme your body uses to break down Lipitor. This means that the drug stays in your body longer when it interacts with grapefruit. Atorvastatin (Lipitor) is an inexpensive drug that lowers levels of cholesterol and triglycerides in the blood. Atorvastatin may also reduce the risk of heart attack or stroke in patients with risk factors for heart disease. Grapefruit is a delicious citrus fruit with many health benefits. However, it can interact with some common medications, altering their effects on your body. Grapefruit is 92% water, giving it one of the highest water contents of any fruit. That makes it good for overall health. (It's one of our 15 foods that help you stay hydrated.) History. The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published clinical report on grapefruit drug interactions was in 1991 in The Lancet entitled Interactions of Citrus Juices with Felodipine and Nifedipine. The pomelo (also called shaddock, pumelo, pommelo, and Chinese grapefruit) is the largest citrus fruit, ranging from the size of a cantaloupe to that of a large watermelon. How Does Grapefruit Affect Birth Control Effectiveness? Chemicals in grapefruit interfere with an enzyme in the intestines called CYP3A4, which affects how your body breaks down and absorbs. Compare prices, print coupons and get savings tips for Atorvastatin (Generic Lipitor) and other Coronary Artery Disease and High Cholesterol drugs at CVS, Walgreens, and other pharmacies. Prices start at $9.00.